Apoptotic Cell–Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN
نویسندگان
چکیده
منابع مشابه
Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.
Loss of tolerance to neutrophil myeloperoxidase (MPO) underlies the development of ANCA-associated vasculitis and GN, but the mechanisms underlying this loss of tolerance are poorly understood. Here, we assessed the role of the thymus in deletion of autoreactive anti-MPO T cells and the importance of peripheral regulatory T cells in maintaining tolerance to MPO and protecting from GN. Thymic ex...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2019
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2018090955